SCH772984

Name: SCH772984
Brand: Adooq Bioscience
SKU: A12824
Rating: 100 (6 reviews)

Catalog No.: A12824

ERK Inhibitor

Product Citations (6)

SCH772984 Chemical Structure

CAS NO. 942183-80-4

SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.

Availability: In stock

Package	Price	Qty
5 mg	$110.00
10 mg	$170.00
25 mg	$340.00
50 mg	$480.00
Custom Size	Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Bulk Inquiry

Get Free Sample

Price Match

Add to Wishlist

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq SCH772984

Yuki Shimizu, .et al. Acquired resistance to BRAF inhibitors is mediated by BRAF splicing variants in BRAF V600E mutation-positive colorectal neuroendocrine carcinoma, Cancer Lett, 2022, Sep 1;543 PMID: 35724767
Yajun Li, .et al. Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF-??B pathway, Cell Prolif, 2022, Oct;55(10) PMID: 35708050
Sergey A. Dyshlovoy, .et al. Activity of New Synthetic (2-Chloroethylthio)-1,4-naphthoquinones in Prostate Cancer Cells, Pharmaceuticals, 2021, 14(10), 949
Sergey A Dyshlovoy, .et al. Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties, Sci Rep, 2020, Aug 6;10(1):13178 PMID: 32764580
Guo X, .et al. PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus, Pflugers Arch, 2018, Jun;470(6):909-921 PMID: 29441404
Takuya Hasegawa, .et al. ErbB2 signaling epigenetically suppresses microRNA-205 transcription via Ras/Raf/MEK/ERK pathway in breast cancer, FEBS Open Bio, 2017, Aug; 7(8): 1154-1165 PMID: 28781955

Biological Activity

SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.

Targets

ERK2 (Cell-free assay)	ERK1 (Cell-free assay)	MEK1 (Cell-free assay)
1 nM	4 nM	>10 μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 13 mg/mL (22.12 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+ddH2O	0.5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.02 mL	85.08 mL	170.16 mL
0.5 mM	3.4 mL	17.02 mL	34.03 mL
1 mM	1.7 mL	8.51 mL	17.02 mL
5 mM	0.34 mL	1.7 mL	3.4 mL

*The above data is based on the productmolecular weight 587.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A12824
Actions	Inhibitor
CAS No.	942183-80-4
Formula	C33H33N9O2
M. Wt	587.68
Purity	>98%
Synonyms	SCH-772984, SCH 772984
SMILES	C1CN(C[[email protected]@H]1C(=O)NC2=CC3=C(C=C2)NN=C3C4=CC=NC=C4)CC(=O)N5CCN(CC5)C6=CC=C(C=C6)C7=NC=CC=N7
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.