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$0.00 - Sergey A. Dyshlovoy, .et al. Activity of New Synthetic (2-Chloroethylthio)-1,4-naphthoquinones in Prostate Cancer Cells, Pharmaceuticals, 2021, 14(10), 949
- Sergey A Dyshlovoy, .et al. Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties, Sci Rep, 2020, Aug 6;10(1):13178 PMID: 32764580
- Guo X, .et al. PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus, Pflugers Arch, 2018, Jun;470(6):909-921 PMID: 29441404
- Takuya Hasegawa, .et al. ErbB2 signaling epigenetically suppresses microRNA-205 transcription via Ras/Raf/MEK/ERK pathway in breast cancer, FEBS Open Bio, 2017, Aug; 7(8): 1154-1165 PMID: 28781955
Biological Activity
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
Targets
| ERK2 (Cell-free assay) | ERK1 (Cell-free assay) | MEK1 (Cell-free assay) | ||
| 1 nM | 4 nM | >10 μM |
| In vitro (25°C) | DMSO | Warmed: 13 mg/mL (22.12 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+30% PEG 300+ddH2O | 0.5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.02 mL | 85.08 mL | 170.16 mL |
| 0.5 mM | 3.4 mL | 17.02 mL | 34.03 mL |
| 1 mM | 1.7 mL | 8.51 mL | 17.02 mL |
| 5 mM | 0.34 mL | 1.7 mL | 3.4 mL |
*The above data is based on the productmolecular weight 587.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12824 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 942183-80-4 |
| Formula | C33H33N9O2 |
| M. Wt | 587.68 |
| Purity | >98% |
| Synonyms | SCH-772984, SCH 772984 |
| SMILES | C1CN(C[[email protected]@H]1C(=O)NC2=CC3=C(C=C2)NN=C3C4=CC=NC=C4)CC(=O)N5CCN(CC5)C6=CC=C(C=C6)C7=NC=CC=N7 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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