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ERK Inhibitor

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Catalog No. A12824

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SCH772984 5mg A12824-5

Regular Price: $110.00

Special Price: $99.00

SCH772984 10mg A12824-10

Regular Price: $170.00

Special Price: $153.00

SCH772984 25mg A12824-25

Regular Price: $340.00

Special Price: $306.00

SCH772984 50mg A12824-50

Regular Price: $480.00

Special Price: $432.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.


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Publications citing Adooq Products
SCH772984 Citations (2)
  • Guo X, .et al. PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus, Pflugers Arch, 2018, Jun;470(6):909-921 PMID: 29441404
  • Takuya Hasegawa, .et al. ErbB2 signaling epigenetically suppresses microRNA-205 transcription via Ras/Raf/MEK/ERK pathway in breast cancer, FEBS Open Bio, 2017, Aug; 7(8): 1154-1165 PMID: 28781955

Chemical Information

Catalog Num A12824
Actions Inhibitor
M. Wt 587.68
Formula C33H33N9O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 942183-80-4
Synonyms SCH-772984, SCH 772984
SMILES C1CN(C[[email protected]@H]1C(=O)NC2=CC3=C(C=C2)NN=C3C4=CC=NC=C4)CC(=O)N5CCN(CC5)C6=CC=C(C=C6)C7=NC=CC=N7

Biological Activity

SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
ERK2 (Cell-free assay) ERK1 (Cell-free assay) MEK1 (Cell-free assay)
1 nM4 nM>10 μM


Solubility (25°C)* In vitro DMSO 0.1 mg/mL heating (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.02 mL 85.08 mL 170.16mL
0.5 mM 3.4 mL 17.02 mL 34.03 mL
1 mM 1.7 mL 8.51 mL 17.02 mL
5 mM 0.34 mL 1.7 mL 3.4 mL

*The above data is based on the productmolecular weight 587.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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