SD-91 is a selective PROTAC-based degrader targeting STAT3 with a Ki of 5.5 nM, demonstrating over 300-fold selectivity against other STAT family proteins. This compound effectively induces the degradation of STAT3 protein in cellular systems. It shows potential anticancer activity, particularly in myeloid leukemia and lymphoma research applications.
SD-91 is a selective PROTAC-based degrader targeting STAT3 with a Ki of 5.5 nM, demonstrating over 300-fold selectivity against other STAT family proteins. This compound effectively induces the degradation of STAT3 protein in cellular systems. It shows potential anticancer activity, particularly in myeloid leukemia and lymphoma research applications.
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