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SDOX

Catalog No.: A57132
Doxorubicin Prodrug
SDOX is a doxorubicin prodrug designed to release the active compound doxorubicin in response to elevated levels of glutathione (GSH) found in tumor cells. This targeted mechanism minimizes adverse effects on healthy tissues while maintaining the therapeutic efficacy of doxorubicin. SDOX is suitable for research applications focused on cancer treatment and overcoming multidrug resistance.
SDOX 2921601-78-5 Doxorubicin Prodrug
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Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSDOX is a doxorubicin prodrug designed to release the active compound doxorubicin in response to elevated levels of glutathione (GSH) found in tumor cells. This targeted mechanism minimizes adverse effects on healthy tissues while maintaining the therapeutic efficacy of doxorubicin. SDOX is suitable for research applications focused on cancer treatment and overcoming multidrug resistance.
Product Information
Catalog NumA57132
FormulaC69H97NO20S2
Molecular Weight1324.63
CAS Number2921601-78-5
SMILESC[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OCCOCCOCCOC(CCC(OCCSSCCOC(N[C@H]4C[C@@H](O[C@H]([C@H]4O)C)O[C@@H]5C6=C(C[C@](O)(C5)C(CO)=O)C(O)=C7C(C(C8=C(OC)C=CC=C8C7=O)=O)=C6O)=O)=O)=O)([H])[C@@]9([H])[C@](CC3)([C@@](CC9)([H])[C@H](C)CCCC(C)C)C
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DNA Damage > Topoisomerase