Sematilide hydrochloride is a selective blocker of the IKr channel, primarily involved in cardiac repolarization. It exhibits a concentration-dependent inhibition of the delayed rectifier K+ current, with an IC50 value of 25 μM. As a class III antiarrhythmic agent, sematilide is utilized in research to study heart rhythm disorders and the underlying mechanisms of arrhythmias.
Sematilide hydrochloride is a selective blocker of the IKr channel, primarily involved in cardiac repolarization. It exhibits a concentration-dependent inhibition of the delayed rectifier K+ current, with an IC50 value of 25 μM. As a class III antiarrhythmic agent, sematilide is utilized in research to study heart rhythm disorders and the underlying mechanisms of arrhythmias.
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