Sesaminol is an oral Nrf2-ARE pathway activator that promotes nuclear translocation of Nrf2 and enhances expression of NQO1, thereby bolstering cellular defense against oxidative stress. This compound has been shown to inhibit 6-OHDA-induced ROS production and apoptosis in SH-SY5Y cells. Additionally, sesaminol demonstrates neuroprotective effects in models of Parkinson's disease induced by Rotenone, making it a valuable tool for research into neuroprotection and oxidative stress response mechanisms.
Sesaminol is an oral Nrf2-ARE pathway activator that promotes nuclear translocation of Nrf2 and enhances expression of NQO1, thereby bolstering cellular defense against oxidative stress. This compound has been shown to inhibit 6-OHDA-induced ROS production and apoptosis in SH-SY5Y cells. Additionally, sesaminol demonstrates neuroprotective effects in models of Parkinson's disease induced by Rotenone, making it a valuable tool for research into neuroprotection and oxidative stress response mechanisms.
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