SGC 0946

Catalog No.: A12941

DOT1L inhibitor

SGC 0946

SGC 0946 Chemical Structure

CAS NO. 1561178-17-3

SGC 0946 is a potent DOT1L methyltransferase inhibitor that blocks H3K79 methylation in A431 cells and MCF10A cells.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$100.00
25 mg
$200.00
50 mg
$350.00
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Biological Activity

SGC 0946 is a potent DOT1L methyltransferase inhibitor that blocks H3K79 methylation in A431 cells and MCF10A cells.
Targets
DOT1L (Cell-free assay)
0.3 nM
In vitro DMSO 98 mg/mL (158.43 mM)
Water Insoluble
Ethanol 98 mg/mL (158.43 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.17 mL 80.83 mL 161.66 mL
0.5 mM 3.23 mL 16.17 mL 32.33 mL
1 mM 1.62 mL 8.08 mL 16.17 mL
5 mM 0.32 mL 1.62 mL 3.23 mL

*The above data is based on the productmolecular weight 618.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12941
Actions Inhibitor
CAS No. 1561178-17-3
Formula C28H40BrN7O4
M. Wt 618.57
Purity >98%
Synonyms SGC0946, SGC-0946
SMILES CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[[email protected]@H]2[[email protected]]([[email protected]]([[email protected]@H](O2)N3C(=CC4=C3N=CN=C4N)Br)O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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