ShK-Dap22 is a highly selective Kv1.3 channel blocker, exhibiting potent immunosuppressive properties with IC50 values of 23 pM for mKv1.3, 1.8 nM for mKv1.1, 10.5 nM for hKv1.6, 37 nM for mKv1.4, and 39 nM for rKv1.2. This polypeptide is primarily utilized in research focused on autoimmune diseases and T cell modulation, enhancing the understanding of Kv1.3's role in immune responses. Its high specificity for Kv1.3 makes it a valuable tool for investigating immune cell function and potential therapeutic pathways.
ShK-Dap22 is a highly selective Kv1.3 channel blocker, exhibiting potent immunosuppressive properties with IC50 values of 23 pM for mKv1.3, 1.8 nM for mKv1.1, 10.5 nM for hKv1.6, 37 nM for mKv1.4, and 39 nM for rKv1.2. This polypeptide is primarily utilized in research focused on autoimmune diseases and T cell modulation, enhancing the understanding of Kv1.3's role in immune responses. Its high specificity for Kv1.3 makes it a valuable tool for investigating immune cell function and potential therapeutic pathways.
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