SJ-C1044 is a pan-RAF inhibitor that demonstrates both immunomodulatory and anti-tumor properties. This compound effectively targets wild-type BRAF, wild-type CRAF, and BRAF (V600E) with IC50 values of 331, 257, and 187 nM, respectively, leading to inhibition of Kras activation and MEK-ERK phosphorylation, which reduces tumor cell proliferation. Additionally, SJ-C1044 exhibits inhibitory effects on VEGFR2, TIE2, and CSF1R, with IC50 values of 100, 23, and 235 nM, respectively, contributing to the improvement of the tumor immune microenvironment via the inhibition of angiogenesis and modulation of macrophage function. SJ-C1044 is suitable for research applications in colorectal cancer studies.
SJ-C1044 is a pan-RAF inhibitor that demonstrates both immunomodulatory and anti-tumor properties. This compound effectively targets wild-type BRAF, wild-type CRAF, and BRAF (V600E) with IC50 values of 331, 257, and 187 nM, respectively, leading to inhibition of Kras activation and MEK-ERK phosphorylation, which reduces tumor cell proliferation. Additionally, SJ-C1044 exhibits inhibitory effects on VEGFR2, TIE2, and CSF1R, with IC50 values of 100, 23, and 235 nM, respectively, contributing to the improvement of the tumor immune microenvironment via the inhibition of angiogenesis and modulation of macrophage function. SJ-C1044 is suitable for research applications in colorectal cancer studies.
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