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SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17?nM, but does not degrade p38α, p38β, or p38γ.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 8.56 mL | 42.8 mL | 85.6 mL |
| 0.5 mM | 1.71 mL | 8.56 mL | 17.12 mL |
| 1 mM | 0.86 mL | 4.28 mL | 8.56 mL |
| 5 mM | 0.17 mL | 0.86 mL | 1.71 mL |
*The above data is based on the productmolecular weight 1168.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18599 |
|---|---|
| CAS No. | 2254609-23-7 |
| Formula | C62H63F2N7O12S |
| M. Wt | 1168.27 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | SJF δ, SJF-δ, SJF-delta |
| SMILES | FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCOCCOCCOC5=CC(C6=C(C)N=CS6)=CC=C5CNC([[email protected]@H]7C[[email protected]@H](O)CN7C([[email protected]@H](N8C(C9=CC=CC=C9C8)=O)C(C)C)=O)=O)=C%10)C%10=NC=C4)C=C3)=O)=O)C=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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