SM-15178 is a selective leukotriene B4 (LTB4) receptor antagonist with an IC50 of 0.30 μM, exhibiting potent oral bioactivity. This compound effectively reduces LTB4-induced neutrophil accumulation in murine models and alleviates bronchoconstriction in guinea pig studies. SM-15178 shows significant anti-inflammatory properties and is valuable for investigating chronic inflammatory conditions, including inflammatory bowel disease, psoriasis, and asthma.
SM-15178 is a selective leukotriene B4 (LTB4) receptor antagonist with an IC50 of 0.30 μM, exhibiting potent oral bioactivity. This compound effectively reduces LTB4-induced neutrophil accumulation in murine models and alleviates bronchoconstriction in guinea pig studies. SM-15178 shows significant anti-inflammatory properties and is valuable for investigating chronic inflammatory conditions, including inflammatory bowel disease, psoriasis, and asthma.
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