SN 38
SN 38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor).
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Adooq Products cited in reputable paper
Adooq's SN 38 has been cited by 5 publications
- Akari Shiraishi, .et al. , Biochem Biophys Res Commun, 2024, Jun 11:725:150255 PMID: 38897043
- Sarigama Rajesh, .et al. , Pharmaceutics, 2022, Oct 12;14(10):2175 PMID: 36297610
- Chen JC, .et al. , Biomolecules, 2019, Sep 9;9(9) PMID: 31505885
- Alibolandi M, .et al. , Artif Cells Nanomed Biotechnol, 2018, May 27:1-12 PMID: 29806500
- Bar-Zeev M, .et al. , Eur J Pharm Biopharm, 2018, Dec;133:240-249 PMID: 30367935
Biological Activity
| Description | SN 38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor). | |||||
|---|---|---|---|---|---|---|
| Targets |
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| Cell Research |
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Product Information
| Catalog Num | A12011 |
|---|---|
| Formula | C22H20N2O5 |
| Molecular Weight | 392.4 |
| CAS Number | 86639-52-3 |
| SMILES | CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)[C@@]5(CC)O)O |
| Synonyms | 7-Ethyl-10-hydroxycamptothecin, SN38, SN-38 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro | DMSO | 20 mg/mL (50.96 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.48 mL | 127.42 mL | 254.84 mL |
| 0.5 mM | 5.1 mL | 25.48 mL | 50.97 mL |
| 1 mM | 2.55 mL | 12.74 mL | 25.48 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
