SN 38

Catalog No.: A12011

DNA topoisomerase Inhibitor

SN 38

SN 38 Chemical Structure

CAS NO. 86639-52-3

SN 38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor).

Availability: In stock

Package Price Qty
50 mg
$60.00
100 mg
$80.00
250 mg
$160.00
10mM * 1mL in DMSO
$85.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Chen JC, .et al. In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells, Biomolecules, 2019, Sep 9;9(9) PMID: 31505885
  • Alibolandi M, .et al. Tetrac-decorated chitosan-coated PLGA nanoparticles as a new platform for targeted delivery of SN38, Artif Cells Nanomed Biotechnol, 2018, May 27:1-12 PMID: 29806500
  • Bar-Zeev M, .et al. β-Casein micelles for oral delivery of SN-38 and elacridar to overcome BCRP-mediated multidrug resistance in gastric cancer, Eur J Pharm Biopharm, 2018, Dec;133:240-249 PMID: 30367935

Biological Activity

SN 38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor).
Targets
Topo I (Cell-free assay)
In vitro DMSO 20 mg/mL (50.96 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.48 mL 127.42 mL 254.84 mL
0.5 mM 5.1 mL 25.48 mL 50.97 mL
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL

*The above data is based on the productmolecular weight 392.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12011
Actions Inhibitor
CAS No. 86639-52-3
Formula C22H20N2O5
M. Wt 392.4
Purity >98%
Synonyms 7-Ethyl-10-hydroxycamptothecin, SN38, SN-38
SMILES CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)[[email protected]@]5(CC)O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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