SN-398 is a potent inhibitor of mammalian DNA topoisomerase I (Topo I), functioning by stabilizing the Topo I-DNA complex and preventing DNA rewiring, which leads to Topo I-mediated DNA breaks. This derivative of Camptothecin demonstrates enhanced antitumor activity compared to SN-38, with an IC50 value of 1.562 μM in HeLa cell assays. SN-398 serves as a valuable tool for investigating the mechanisms of anti-proliferation and growth inhibition related to Topo I in various cancer cell models.
SN-398 is a potent inhibitor of mammalian DNA topoisomerase I (Topo I), functioning by stabilizing the Topo I-DNA complex and preventing DNA rewiring, which leads to Topo I-mediated DNA breaks. This derivative of Camptothecin demonstrates enhanced antitumor activity compared to SN-38, with an IC50 value of 1.562 μM in HeLa cell assays. SN-398 serves as a valuable tool for investigating the mechanisms of anti-proliferation and growth inhibition related to Topo I in various cancer cell models.
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