Sob-AM2 is a high-affinity substrate for fatty acid amide hydrolase (FAAH), exhibiting a Km of 1.3 μM and demonstrating effective blood-brain barrier permeability. This compound facilitates elevated delivery of Sobetirome to the central nervous system while minimizing peripheral exposure, thus activating central thyroid hormone receptor β (TRβ). Additionally, Sob-AM2 has been shown to protect against myelin and axon degeneration in models of experimental autoimmune encephalomyelitis (EAE), making it a valuable tool for investigating neuroprotective mechanisms and central nervous system disorders.
Sob-AM2 is a high-affinity substrate for fatty acid amide hydrolase (FAAH), exhibiting a Km of 1.3 μM and demonstrating effective blood-brain barrier permeability. This compound facilitates elevated delivery of Sobetirome to the central nervous system while minimizing peripheral exposure, thus activating central thyroid hormone receptor β (TRβ). Additionally, Sob-AM2 has been shown to protect against myelin and axon degeneration in models of experimental autoimmune encephalomyelitis (EAE), making it a valuable tool for investigating neuroprotective mechanisms and central nervous system disorders.
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