Spiradoline is a selective κ-opioid receptor (KOR) agonist, demonstrating a Ki of 8.6 nM in guinea pig models. With significantly higher Ki values for μ and δ receptors at 252 nM and 9400 nM, respectively, Spiradoline exhibits notable biological activities, including analgesic, diuretic, antiarrhythmic, antitussive, and neuroprotective effects. Its ability to effectively penetrate the blood-brain barrier makes it a valuable reagent for research in pain management and neurological studies.
Spiradoline is a selective κ-opioid receptor (KOR) agonist, demonstrating a Ki of 8.6 nM in guinea pig models. With significantly higher Ki values for μ and δ receptors at 252 nM and 9400 nM, respectively, Spiradoline exhibits notable biological activities, including analgesic, diuretic, antiarrhythmic, antitussive, and neuroprotective effects. Its ability to effectively penetrate the blood-brain barrier makes it a valuable reagent for research in pain management and neurological studies.
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