SR-14968 is a full allosteric and non-competitive agonist of the mu-opioid receptor (MOR), exhibiting an EC50 of 88 nM in mouse brainstem assays. This compound stabilizes the MOR in a G protein signaling state that demonstrates resistance to washout, while remaining reversible by antagonists. SR-14968 is capable of inducing respiratory depression in murine models, making it a valuable tool for exploring pain-related mechanisms and the pharmacological effects of MOR activation in research settings.
SR-14968 is a full allosteric and non-competitive agonist of the mu-opioid receptor (MOR), exhibiting an EC50 of 88 nM in mouse brainstem assays. This compound stabilizes the MOR in a G protein signaling state that demonstrates resistance to washout, while remaining reversible by antagonists. SR-14968 is capable of inducing respiratory depression in murine models, making it a valuable tool for exploring pain-related mechanisms and the pharmacological effects of MOR activation in research settings.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
