SR 47063 is an ATP-sensitive potassium channel (KATP) agonist that selectively activates KATP channels in vascular smooth muscle cells, exhibiting an IC50 of 8.1 nM in human saphenous vein and 3.86 nM in rat aorta. By promoting potassium efflux and inducing cellular hyperpolarization, SR 47063 facilitates vasorelaxation. This compound is valuable for research into hypertension and associated cardiovascular disorders.
SR 47063 is an ATP-sensitive potassium channel (KATP) agonist that selectively activates KATP channels in vascular smooth muscle cells, exhibiting an IC50 of 8.1 nM in human saphenous vein and 3.86 nM in rat aorta. By promoting potassium efflux and inducing cellular hyperpolarization, SR 47063 facilitates vasorelaxation. This compound is valuable for research into hypertension and associated cardiovascular disorders.
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