STAT3-IN-35 is a selective inhibitor of Signal Transducer and Activator of Transcription 3 (STAT3) that targets the SH2 domain. This compound effectively inhibits STAT3 phosphorylation, demonstrating significant antiproliferative effects in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 exhibits pronounced antitumor activity and toxicity in TNBC xenograft models, making it a valuable tool for cancer research and therapeutic development.
STAT3-IN-35 is a selective inhibitor of Signal Transducer and Activator of Transcription 3 (STAT3) that targets the SH2 domain. This compound effectively inhibits STAT3 phosphorylation, demonstrating significant antiproliferative effects in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 exhibits pronounced antitumor activity and toxicity in TNBC xenograft models, making it a valuable tool for cancer research and therapeutic development.
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