Stiripentol-d9 is a deuterium-labeled variant of the anticonvulsant Stiripentol. This compound acts primarily by noncompetitively inhibiting N-demethylation of clonazepam (CLB) to its active form, N-desmethylclonazepam (NCLB), via CYP3A4 and competitively via CYP2C19, with measured inhibition constants (Kis) of 1.59±0.07 μM and 0.516±0.065 μM, respectively. With an IC50 of 1.58 μM for CYP3A4 and 3.29 μM for CYP2C19, Stiripentol-d9 is valuable for studying metabolic pathways and the pharmacokinetics of antiepileptic drugs.
Stiripentol-d9 is a deuterium-labeled variant of the anticonvulsant Stiripentol. This compound acts primarily by noncompetitively inhibiting N-demethylation of clonazepam (CLB) to its active form, N-desmethylclonazepam (NCLB), via CYP3A4 and competitively via CYP2C19, with measured inhibition constants (Kis) of 1.59±0.07 μM and 0.516±0.065 μM, respectively. With an IC50 of 1.58 μM for CYP3A4 and 3.29 μM for CYP2C19, Stiripentol-d9 is valuable for studying metabolic pathways and the pharmacokinetics of antiepileptic drugs.
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