SU-5402

SU-5402 Chemical Structure

CAS NO. 215543-92-3

SU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively).

Availability: In stock

Package Price Qty
5 mg
$36.00
10 mg
$61.00
25 mg
$108.00
50 mg
$180.00
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Biological Activity

SU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively).
Targets
VEGFR2 FGFR1 PDGFRβ
20 nM30 nM510 nM
In vitro DMSO 54 mg/mL (182.23 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.75 mL 168.74 mL 337.47 mL
0.5 mM 6.75 mL 33.75 mL 67.49 mL
1 mM 3.37 mL 16.87 mL 33.75 mL
5 mM 0.67 mL 3.37 mL 6.75 mL

*The above data is based on the productmolecular weight 296.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11558
Actions Inhibitor
CAS No. 215543-92-3
Formula C17H16N2O3
M. Wt 296.32
Purity >98%
Synonyms SU5402, SU 5402
SMILES CC1=CNC(=C1CCC(=O)O)/C=C\2/C3=CC=CC=C3NC2=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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