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Biological Activity
SU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively).
Targets
| VEGFR2 | FGFR1 | PDGFRβ | ||
| 20 nM | 30 nM | 510 nM |
| In vitro | DMSO | 54 mg/mL (182.23 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.75 mL | 168.74 mL | 337.47 mL |
| 0.5 mM | 6.75 mL | 33.75 mL | 67.49 mL |
| 1 mM | 3.37 mL | 16.87 mL | 33.75 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
*The above data is based on the productmolecular weight 296.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11558 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 215543-92-3 |
| Formula | C17H16N2O3 |
| M. Wt | 296.32 |
| Purity | >98% |
| Synonyms | SU5402, SU 5402 |
| SMILES | CC1=CNC(=C1CCC(=O)O)/C=C\2/C3=CC=CC=C3NC2=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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