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Synstatin (92-119)

Catalog No.: A57407
αvβ3/αvβ5 integrin/IGF1R Inhibitor
Synstatin (92-119) is a potent inhibitor targeting αvβ3/αvβ5 integrins and IGF1R, exhibiting anti-angiogenic, anti-proliferative, antioxidant, and anti-tumor properties. It functions by competitively inhibiting the interaction of syndecan-1 with these integrins and IGF1R, thereby disrupting the ternary complex formation and blocking critical downstream signaling pathways. This compound is particularly relevant for research in cancer biology, especially in studies focused on angiogenesis and hepatocellular carcinoma.
Synstatin (92-119) 1259384-47-8 αvβ3/αvβ5 integrin/IGF1R Inhibitor
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Size Price Stock Qty
1mg
$40.00
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5mg
$125.00
In stock
10mg
$210.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSynstatin (92-119) is a potent inhibitor targeting αvβ3/αvβ5 integrins and IGF1R, exhibiting anti-angiogenic, anti-proliferative, antioxidant, and anti-tumor properties. It functions by competitively inhibiting the interaction of syndecan-1 with these integrins and IGF1R, thereby disrupting the ternary complex formation and blocking critical downstream signaling pathways. This compound is particularly relevant for research in cancer biology, especially in studies focused on angiogenesis and hepatocellular carcinoma.
Product Information
Catalog NumA57407
FormulaC133H207N35O46
Molecular Weight3032.27
CAS Number1259384-47-8
SequenceLeu-Pro-Ala-Gly-Glu-Lys-Pro-Glu-Glu-Gly-Glu-Pro-Val-Leu-His-Val-Glu-Ala-Glu-Pro-Gly-Phe-Thr-Ala-Arg-Asp-Lys-Glu
Sequence shorteningLPAGEKPEEGEPVLHVEAEPGFTARDKE
SMILESC([C@@H](NC([C@@H](NC(CNC([C@@H](NC(=O)[C@H]1N(C([C@H](CC(C)C)N)=O)CCC1)C)=O)=O)CCC(O)=O)=O)CCCCN)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CN=CN4)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N5[C@H](C(NCC(N[C@@H](CC6=CC=CC=C6)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)CCCCN)=O)CC(O)=O)=O)CCCNC(=N)N)=O)C)=O)[C@@H](C)O)=O)=O)=O)CCC5)CCC(O)=O)=O)C)=O)CCC(O)=O)=O)C(C)C)=O)=O)CC(C)C)=O)[C@@H](C)C)=O)CCC3)CCC(O)=O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC2
SynonymsSSTN92-119
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Cytoskeleton > Integrin