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- Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
- Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
|Storage||at -20°C 3 years Powder|
|Synonyms||NVP-TAE684 , TAE-684|
|TAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant).|
|Solubility (25°C) *||In vitro||DMSO||3 mg/mL (4.88 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||30% PEG400/0.5% Tween80/5% propylene glycol, pH 4||10 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||16.28 mL||81.41 mL||162.81mL|
|0.5 mM||3.26 mL||16.28 mL||32.56 mL|
|1 mM||1.63 mL||8.14 mL||16.28 mL|
|5 mM||0.33 mL||1.63 mL||3.26 mL|
*The above data is based on the productmolecular weight 614.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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