TAE684

Catalog No.: A10662

ALK Inhibitor

TAE684

TAE684 Chemical Structure

CAS NO. 761439-42-3

TAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant).

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Package Price Qty
5 mg
$80.00
10 mg
$120.00
50 mg
$320.00
100 mg
$450.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
  • Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190

Biological Activity

TAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant).
Targets
ALK (Cell-free assay)
3 nM
In vitro (25°C) DMSO 3 mg/mL (4.88 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol, pH 4 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.28 mL 81.41 mL 162.81 mL
0.5 mM 3.26 mL 16.28 mL 32.56 mL
1 mM 1.63 mL 8.14 mL 16.28 mL
5 mM 0.33 mL 1.63 mL 3.26 mL

*The above data is based on the productmolecular weight 614.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10662
Actions Inhibitor
M. Wt 614.2
Formula C30H40ClN7O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 761439-42-3
Synonyms NVP-TAE684 , TAE-684
SMILES CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC

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