Tagarafdeg is a CRBN-based bifunctional degradation activating compound (BiDAC) selectively targeting BRAFV600E mutations. Demonstrating potent activity with a DC50 of 14 nM in A375 cells, it effectively degrades various BRAF mutations, including G469A and G466V, as well as the p61-BRAFV600E splice variant. This reagent is suitable for applications in tumor research, contributing to the understanding of BRAF-mediated oncogenic processes.
Tagarafdeg is a CRBN-based bifunctional degradation activating compound (BiDAC) selectively targeting BRAFV600E mutations. Demonstrating potent activity with a DC50 of 14 nM in A375 cells, it effectively degrades various BRAF mutations, including G469A and G466V, as well as the p61-BRAFV600E splice variant. This reagent is suitable for applications in tumor research, contributing to the understanding of BRAF-mediated oncogenic processes.
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