Signaling Pathway
Product type
Important Notice: For research use only. We do not sell to patients.
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| Discription | TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio. | |||||
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| Cell Research |
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| Catalog Num | A13323 |
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| Formula | C27H18F4N4O3S |
| Molecular Weight | 554.51 |
| CAS Number | 1228591-30-7 |
| SMILES | C1CC1C(=O)NC2=NC3=C(S2)C(=C(C=C3)OC4=CC(=C(C=C4)F)NC(=O)CC5=CC(=CC=C5)C(F)(F)F)C#N |
| Synonyms | TAK 632; TAK632 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 99 mg/mL (178.53 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL (3.6 mM) | ||
| In vivo | 2% DMSO+98% PEG 300 | 4 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.03 mL | 90.17 mL | 180.34 mL |
| 0.5 mM | 3.61 mL | 18.03 mL | 36.07 mL |
| 1 mM | 1.8 mL | 9.02 mL | 18.03 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.61 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
