World Leading Inhibitor Supplier

France
  • Toll Free 866-930-6790
Trusted by 10,000+ Scientists since 2006

TAK-632

pan-RAF inhibitor

0 Customer Reviews
Catalog No. A13323

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
TAK-632 5mg A13323-5
€61.75
TAK-632 10mg A13323-10
€95.00
TAK-632 25mg A13323-25
€190.00
TAK-632 50mg A13323-50
€285.00
TAK-632 10mM * 1mL in DMSO A13323-10mM-D
€76.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

TAK-632 is a potent pan-RAF inhibitor with favorable in
vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.

TAK-632

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Publications citing Adooq Products
TAK-632 Citations (1)
  • Yosi Shamay, .et al. Quantitative Self-Assembly Prediction Yields Targeted Nanomedicines, Nat Mater, 2018, Apr; 17(4): 361每368 PMID: 29403054

Chemical Information

Catalog Num A13323
Actions Inhibitor
M. Wt 554.51
Formula C27H18F4N4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1228591-30-7
Synonyms TAK 632; TAK632
SMILES C1CC1C(=O)NC2=NC3=C(S2)C(=C(C=C3)OC4=CC(=C(C=C4)F)NC(=O)CC5=CC(=CC=C5)C(F)(F)F)C#N

Biological Activity

Description
 TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.
Targets
Target Value
C-RafIC50: 1.4nM
B-RafIC50: 8.3nM
AuroraBIC50: 66nM
PDGFRβIC50: 120nM
FGFR3IC50: 280nM
GSK-3βIC50: 500nM
CDK2IC50: 580nM
p38αIC50: 600nM
PDGFRαIC50: 610nM
Tie-2IC50: 740nM
CDK1IC50: 790nM
Chk1IC50: 1.4μM
MEK1IC50: 3.7μM
IKKβIC50: 3.7μM
PKAIC50: >10μM
PKCθIC50: >10μM
CK1δIC50: >10μM
ERK1IC50: >10μM
EGFRIC50: >10μM
HER2IC50: >10μM
JNK1IC50: >10μM
c-MetIC50: >10μM
c-KitIC50: >10μM
SrcIC50: >10μM
IRIC50: >10μM
MEKK1IC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL (180.33 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (3.6 mM)
In vivo 2% DMSO/98% PEG 300 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.03 mL 90.17 mL 180.34mL
0.5 mM 3.61 mL 18.03 mL 36.07 mL
1 mM 1.8 mL 9.02 mL 18.03 mL
5 mM 0.36 mL 1.8 mL 3.61 mL

*The above data is based on the productmolecular weight 554.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Be the first to review this product

Similar product(s)


Keywords:buy TAK-632 | TAK-632 Supplier | purchase TAK-632 | TAK-632 cost | TAK-632 manufacturer | order TAK-632 | TAK-632 distributor | buy 1228591-30-7| 1228591-30-7 Supplier | purchase 1228591-30-7 | 1228591-30-7 cost | 1228591-30-7 manufacturer | order 1228591-30-7 | 1228591-30-7 distributor

Receive our newsletter

To keep up to date with the latest products, news from us. We only send a few emails a year and you can unsubscribe at any time.

We Using Safe Payments:
© 2006-2018 AdooQ BioScience. All Rights Reserved.