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pan-RAF inhibitor

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Catalog No. A13323

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
TAK-632 5mg A13323-5
TAK-632 10mg A13323-10
TAK-632 25mg A13323-25
TAK-632 50mg A13323-50
TAK-632 10mM * 1mL in DMSO A13323-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

TAK-632 is a potent pan-RAF inhibitor with favorable in
vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.


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Publications citing Adooq Products
TAK-632 Citations (1)
  • Yosi Shamay, .et al. Quantitative Self-Assembly Prediction Yields Targeted Nanomedicines, Nat Mater, 2018, Apr; 17(4): 361-368 PMID: 29403054

Chemical Information

Catalog Num A13323
Actions Inhibitor
M. Wt 554.51
Formula C27H18F4N4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1228591-30-7
Synonyms TAK 632; TAK632

Biological Activity

TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.
Target Value
C-RafIC50: 1.4nM
B-RafIC50: 8.3nM
AuroraBIC50: 66nM
PDGFRβIC50: 120nM
FGFR3IC50: 280nM
GSK-3βIC50: 500nM
CDK2IC50: 580nM
p38αIC50: 600nM
PDGFRαIC50: 610nM
Tie-2IC50: 740nM
CDK1IC50: 790nM
Chk1IC50: 1.4μM
MEK1IC50: 3.7μM
IKKβIC50: 3.7μM
PKAIC50: >10μM
PKCθIC50: >10μM
CK1δIC50: >10μM
ERK1IC50: >10μM
EGFRIC50: >10μM
HER2IC50: >10μM
JNK1IC50: >10μM
c-MetIC50: >10μM
c-KitIC50: >10μM
SrcIC50: >10μM
IRIC50: >10μM
MEKK1IC50: >10μM


Solubility (25°C) * In vitro DMSO 100 mg/mL (180.33 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (3.6 mM)
In vivo 2% DMSO/98% PEG 300 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.03 mL 90.17 mL 180.34mL
0.5 mM 3.61 mL 18.03 mL 36.07 mL
1 mM 1.8 mL 9.02 mL 18.03 mL
5 mM 0.36 mL 1.8 mL 3.61 mL

*The above data is based on the productmolecular weight 554.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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