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TAK-632

TAK-632

Name: TAK-632
Brand: Adooq Bioscience
SKU: A13323
Rating: 100 (1 reviews)

Catalog No.: A13323

pan-RAF inhibitor

Product Citations (1)

TAK-632 Chemical Structure

CAS NO. 1228591-30-7

TAK-632 is a potent pan-RAF inhibitor with favorable in
vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.

Availability: In stock

Package	Price	Qty
10 mg	Regular Price: $39.00 Special Price $31.20
25 mg	Regular Price: $69.00 Special Price $55.20
50 mg	Regular Price: $115.00 Special Price $92.00
10mM * 1mL in DMSO	Regular Price: $80.00 Special Price $64.00
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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq TAK-632

Yosi Shamay, .et al. Quantitative Self-Assembly Prediction Yields Targeted Nanomedicines, Nat Mater, 2018, Apr; 17(4): 361-368 PMID: 29403054

Biological Activity

TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.

Targets

Target	Value
C-Raf	IC50: 1.4nM
B-Raf	IC50: 8.3nM
AuroraB	IC50: 66nM
PDGFRβ	IC50: 120nM
FGFR3	IC50: 280nM
GSK-3β	IC50: 500nM
CDK2	IC50: 580nM
p38α	IC50: 600nM
PDGFRα	IC50: 610nM
Tie-2	IC50: 740nM
CDK1	IC50: 790nM
Chk1	IC50: 1.4μM
MEK1	IC50: 3.7μM
IKKβ	IC50: 3.7μM
PKA	IC50: >10μM
PKCθ	IC50: >10μM
CK1δ	IC50: >10μM
ERK1	IC50: >10μM
EGFR	IC50: >10μM
HER2	IC50: >10μM
JNK1	IC50: >10μM
c-Met	IC50: >10μM
c-Kit	IC50: >10μM
Src	IC50: >10μM
IR	IC50: >10μM
MEKK1	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	99 mg/mL (178.53 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (3.6 mM)
In vivo	2% DMSO+98% PEG 300	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.03 mL	90.17 mL	180.34 mL
0.5 mM	3.61 mL	18.03 mL	36.07 mL
1 mM	1.8 mL	9.02 mL	18.03 mL
5 mM	0.36 mL	1.8 mL	3.61 mL

*The above data is based on the productmolecular weight 554.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A13323
Actions	Inhibitor
CAS No.	1228591-30-7
Formula	C27H18F4N4O3S
M. Wt	554.51
Purity	>98%
Synonyms	TAK 632; TAK632
SMILES	C1CC1C(=O)NC2=NC3=C(S2)C(=C(C=C3)OC4=CC(=C(C=C4)F)NC(=O)CC5=CC(=CC=C5)C(F)(F)F)C#N
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.