TAK-960 hydrochloride

Catalog No.: A21703

PLK1 inhibitor

TAK-960 hydrochloride

TAK-960 hydrochloride Chemical Structure

CAS NO. 1137868-96-2

TAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM at 10 μM ATP; TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively.

Availability: In stock

Package Price Qty
1 mg
$320.00
5 mg
$960.00
10 mg
$1,600.00
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Biological Activity

TAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM at 10 μM ATP; TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.72 mL 83.6 mL 167.21 mL
0.5 mM 3.34 mL 16.72 mL 33.44 mL
1 mM 1.67 mL 8.36 mL 16.72 mL
5 mM 0.33 mL 1.67 mL 3.34 mL

*The above data is based on the productmolecular weight 598.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21703
Actions Inhibitor
CAS No. 1137868-96-2
Formula C27H35ClF3N7O3
M. Wt 598.06
Purity >98%
Synonyms TAK 960, TAK960
SMILES CN1CCC(CC1)NC(=O)C2=CC(=C(C=C2F)NC3=NC=C4C(=N3)N(CC(C(=O)N4C)(F)F)C5CCCC5)OC.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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