Tauro-β-muricholic acid (TβMCA) serves as a competitive and reversible antagonist of the farnesoid X receptor (FXR), exhibiting an IC50 of 40 μM. This trihydroxylated bile acid demonstrates significant ability to inhibit bile acid-induced hepatocyte apoptosis by preserving mitochondrial membrane potential and hindering FXR signaling. It influences bile acid synthesis, hepatic lipid metabolism, and insulin sensitivity, while its accumulation can disrupt metabolic homeostasis, facilitating cancer stem cell proliferation and tumor progression. TβMCA is valuable in studies related to bile acid metabolism disorders, non-alcoholic fatty liver disease, colorectal cancer, and liver fibrosis, owing to its dual functionality in stabilizing mitochondrial integrity and regulating hepatic metabolism.
Tauro-β-muricholic acid (TβMCA) serves as a competitive and reversible antagonist of the farnesoid X receptor (FXR), exhibiting an IC50 of 40 μM. This trihydroxylated bile acid demonstrates significant ability to inhibit bile acid-induced hepatocyte apoptosis by preserving mitochondrial membrane potential and hindering FXR signaling. It influences bile acid synthesis, hepatic lipid metabolism, and insulin sensitivity, while its accumulation can disrupt metabolic homeostasis, facilitating cancer stem cell proliferation and tumor progression. TβMCA is valuable in studies related to bile acid metabolism disorders, non-alcoholic fatty liver disease, colorectal cancer, and liver fibrosis, owing to its dual functionality in stabilizing mitochondrial integrity and regulating hepatic metabolism.
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