TBC3486 is a selective inhibitor of integrin α4β1. This compound enhances the sensitivity of leukemia cells to chemotherapy, demonstrating its potential as a chemosensitizer. TBC3486 shows efficacy in preclinical models related to integrin α4-dependent inflammatory and autoimmune conditions, notably in a mouse model of autoimmune encephalomyelitis. It is a valuable reagent for research focused on precursor B-cell acute lymphoblastic leukemia.
TBC3486 is a selective inhibitor of integrin α4β1. This compound enhances the sensitivity of leukemia cells to chemotherapy, demonstrating its potential as a chemosensitizer. TBC3486 shows efficacy in preclinical models related to integrin α4-dependent inflammatory and autoimmune conditions, notably in a mouse model of autoimmune encephalomyelitis. It is a valuable reagent for research focused on precursor B-cell acute lymphoblastic leukemia.
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