TCS ERK 11e (VX-11e)

TCS ERK 11e (VX-11e) Chemical Structure

CAS NO. 896720-20-0

TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM).

Availability: In stock

Package Price Qty
10 mg

Regular Price: $150.00

Special Price $135.00

25 mg

Regular Price: $300.00

Special Price $270.00

50 mg

Regular Price: $500.00

Special Price $450.00

100 mg

Regular Price: $800.00

Special Price $720.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM).
Targets
Target Value
ERK2ki: <2nM
GSK3ki: 400nM
AURAki: 540nM
CDK2ki: 850nM
FLT3ki: 1.4μM
ROCK1ki: 1.4μM
JNK3ki: 1.4μM
TAK1ki: 3μM
PKAki: >4μM
SRCki: >4μM
JAK2ki: >4μM
JAK3ki: >4μM
SYKki: >4μM
METki: >4μM
IRAK4ki: >4μM
AKT3ki: >4μM
KDRki: >4μM
MEK1ki: >4μM
P38αki: >4μM
COTki: >4μM
ITKki: >4μM
MEKK3ki: >4μM
PLK1ki: >4μM
ZAP70ki: >4μM
IKki: ki: >5μM
NIKki: >5μM
CITki: >10μM
FAKki: >10μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.99 mL 99.93 mL 199.86 mL
0.5 mM 4 mL 19.99 mL 39.97 mL
1 mM 2 mL 9.99 mL 19.99 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 500.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12505
Actions Inhibitor
M. Wt 500.35
Formula C24H20Cl2FN5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 896720-20-0
Synonyms N/A
SMILES CC1=CN=C(N=C1C2=CNC(=C2)C(=O)N[[email protected]](CO)C3=CC(=CC=C3)Cl)NC4=C(C=C(C=C4)F)Cl

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