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Tedalinab (GRC-10693) is a drug developed for the treatment of osteoarthritis and neuropathic pain, which acts as a potent and selective cannabinoid CB2 receptor agonist. It has a very high selectivity of 4700x for CB2 over the related CB1 receptor, has good oral bioavailability and has shown promising safety results and effective analgesic and antiinflammatory actions in early clinical trials.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.95 mL | 144.76 mL | 289.52 mL |
| 0.5 mM | 5.79 mL | 28.95 mL | 57.9 mL |
| 1 mM | 2.9 mL | 14.48 mL | 28.95 mL |
| 5 mM | 0.58 mL | 2.9 mL | 5.79 mL |
*The above data is based on the productmolecular weight 345.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Chemical Properties
| Catalog Num | A14189 |
|---|---|
| Actions | Agonist |
| M. Wt | 345.4 |
| Formula | C19H21F2N3O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 916591-01-0 |
| Synonyms | GRC-10693 |
| SMILES | CC(C)(C)NC(=O)C1=NN(C2=C1[[email protected]]3CC[[email protected]@H]2C3)C4=C(C=C(C=C4)F)F |
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