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Biological Activity
Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells.
Targets
| mTOR (Cell-free assay) | ||||
| 1.76 μM |
| In vitro (25°C) | DMSO | 60 mg/mL (58.24 mM) | |
| Water | Insoluble | ||
| Ethanol | 67 mg/mL (65.03 mM) | ||
| In vivo | 2% DMSO+30% PEG 300 +2% Tween 80+ddH2O | 6 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 9.71 mL | 48.53 mL | 97.06 mL |
| 0.5 mM | 1.94 mL | 9.71 mL | 19.41 mL |
| 1 mM | 0.97 mL | 4.85 mL | 9.71 mL |
| 5 mM | 0.19 mL | 0.97 mL | 1.94 mL |
*The above data is based on the productmolecular weight 1030.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10906 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 162635-04-3 |
| Formula | C56H87NO16 |
| M. Wt | 1030.3 |
| Purity | >98% |
| Synonyms | CCI-779 |
| SMILES | C[[email protected]@H]1CC[[email protected]]2C[[email protected]@H](/C(=C/C=C\C=C\[[email protected]](C[[email protected]](C(=O)[[email protected]]([[email protected]](/C(=C\[[email protected]](C(=O)C[[email protected]](OC(=O)[[email protected]@H]3CCCCN3C(=O)C(=O)[[email protected]@]1(O2)O)[[email protected]@H](C)C[[email protected]@H]4CC[[email protected]]([[email protected]@H](C4)OC)OC(=O)C(C)(CO)CO)C)/C)O)OC)C)C)/C)OC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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