Temsirolimus (Torisel)

Catalog No.: A10906

mTOR inhibitor

Temsirolimus (Torisel)

Temsirolimus (Torisel) Chemical Structure

CAS NO. 162635-04-3

Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells.

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$140.00
50 mg
$250.00
200 mg
$600.00
10mM * 1mL in DMSO
$110.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells.
Targets
mTOR (Cell-free assay)
1.76 μM
In vitro (25°C) DMSO 60 mg/mL (58.24 mM)
Water Insoluble
Ethanol 67 mg/mL (65.03 mM)
In vivo 2% DMSO+30% PEG 300 +2% Tween 80+ddH2O 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 9.71 mL 48.53 mL 97.06 mL
0.5 mM 1.94 mL 9.71 mL 19.41 mL
1 mM 0.97 mL 4.85 mL 9.71 mL
5 mM 0.19 mL 0.97 mL 1.94 mL

*The above data is based on the productmolecular weight 1030.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10906
Actions Inhibitor
CAS No. 162635-04-3
Formula C56H87NO16
M. Wt 1030.3
Solubility DMSO
Purity >98%
Synonyms CCI-779
SMILES C[[email protected]@H]1CC[[email protected]]2C[[email protected]@H](/C(=C/C=C\C=C\[[email protected]](C[[email protected]](C(=O)[[email protected]]([[email protected]](/C(=C\[[email protected]](C(=O)C[[email protected]](OC(=O)[[email protected]@H]3CCCCN3C(=O)C(=O)[[email protected]@]1(O2)O)[[email protected]@H](C)C[[email protected]@H]4CC[[email protected]]([[email protected]@H](C4)OC)OC(=O)C(C)(CO)CO)C)/C)O)OC)C)C)/C)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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