Terfenadine

Catalog No.: A17373
H1 histamine receptor antagonist
Terfenadine ((??)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9 and induces p73, Noxa.
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Product Name Price Stock Qty
Terfenadine 100mg
$50.00
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Terfenadine 500mg
$180.00
In stock
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Biological Activity
Discription Terfenadine ((??)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9 and induces p73, Noxa.
Targets
Target Value
Product Information
Catalog Num A17373
Formula C32H41NO2
Molecular Weight 471.685
CAS Number 50679-08-8
SMILES OC(C1=CC=C(C(C)(C)C)C=C1)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2
Synonyms BRN 5857899; BRN5857899; BRN-5857899; Terfenadine; Seldane; Terfen
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO Warmed: 83 mg/mL (175.97 mM)
Water Insoluble
Ethanol Warmed: 24 mg/mL (50.88 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.2 mL 106 mL 212.01 mL
0.5 mM 4.24 mL 21.2 mL 42.4 mL
1 mM 2.12 mL 10.6 mL 21.2 mL
5 mM 0.42 mL 2.12 mL 4.24 mL
Useful Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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