Terfenadine

Catalog No.: A17373

H1 histamine receptor antagonist

Terfenadine

Terfenadine Chemical Structure

CAS NO. 50679-08-8

Terfenadine ((??)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9 and induces p73, Noxa.

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100 mg
$50.00
500 mg
$180.00
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Biological Activity

Terfenadine ((??)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9 and induces p73, Noxa.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.2 mL 106 mL 212.01 mL
0.5 mM 4.24 mL 21.2 mL 42.4 mL
1 mM 2.12 mL 10.6 mL 21.2 mL
5 mM 0.42 mL 2.12 mL 4.24 mL

*The above data is based on the productmolecular weight 471.685. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17373
Actions Antagonist
M. Wt 471.685
Formula C32H41NO2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 50679-08-8
Synonyms BRN 5857899; BRN5857899; BRN-5857899; Terfenadine; Seldane; Terfen
SMILES OC(C1=CC=C(C(C)(C)C)C=C1)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2

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