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$0.00 Biological Activity
Terfenadine ((??)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9 and induces p73, Noxa.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.2 mL | 106 mL | 212.01 mL |
| 0.5 mM | 4.24 mL | 21.2 mL | 42.4 mL |
| 1 mM | 2.12 mL | 10.6 mL | 21.2 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.24 mL |
*The above data is based on the productmolecular weight 471.685. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17373 |
|---|---|
| Actions | Antagonist |
| M. Wt | 471.685 |
| Formula | C32H41NO2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 50679-08-8 |
| Synonyms | BRN 5857899; BRN5857899; BRN-5857899; Terfenadine; Seldane; Terfen |
| SMILES | OC(C1=CC=C(C(C)(C)C)C=C1)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2 |
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