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Tertiapin (reduced)

Catalog No.: A68187
Inward Rectifier K+ Channel Blocker
Tertiapin (reduced) is an inward rectifier K+ channel blocker that effectively inhibits potassium channel activity. Its unique structure, derived from the melittin synthesis, features critical disulfide bonds, enabling selective blockage of calcium-activated large conductance potassium channels. This reagent is valuable for research applications related to various neurological and inflammatory diseases, including rheumatoid arthritis and multiple sclerosis.
Tertiapin (reduced) 58694-52-3 Inward Rectifier K+ Channel Blocker
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTertiapin (reduced) is an inward rectifier K+ channel blocker that effectively inhibits potassium channel activity. Its unique structure, derived from the melittin synthesis, features critical disulfide bonds, enabling selective blockage of calcium-activated large conductance potassium channels. This reagent is valuable for research applications related to various neurological and inflammatory diseases, including rheumatoid arthritis and multiple sclerosis.
Product Information
Catalog NumA68187
FormulaC106H180N34O23S5
Molecular Weight2459.10
CAS Number58694-52-3
SequenceAla-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Met-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2
Sequence shorteningALCNCNRIIIPHMCWKKCGKK-NH2
SMILESC([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)CCCCN)=O)=O)CS)=O)CCCCN)=O)CCCCN)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)N)=O)CC(C)C)=O)CS)=O)CC(N)=O)=O)CS)=O)CC(N)=O)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCC1)CC2=CN=CN2)=O)CCSC)=O)CS)=O)C=3C=4C(NC3)=CC=CC4
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Membrane Transporters-Ion Channels > Potassium Channels