Tesevatinib tosylate is a potent inhibitor of the epidermal growth factor receptor (EGFR), capable of penetrating the blood-brain barrier. This compound exhibits significant cytotoxic effects, demonstrating IC50 values of 11 nM and 102 nM against GBM12 and GBM6 cell lines, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50 = 16.1 nM), VEGFR2 (IC50 = 1.5 nM), and Src (IC50 = 10.3 nM), making it a valuable tool for studying tumor proliferation and antitumor activity in various cancer research applications.
Tesevatinib tosylate is a potent inhibitor of the epidermal growth factor receptor (EGFR), capable of penetrating the blood-brain barrier. This compound exhibits significant cytotoxic effects, demonstrating IC50 values of 11 nM and 102 nM against GBM12 and GBM6 cell lines, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50 = 16.1 nM), VEGFR2 (IC50 = 1.5 nM), and Src (IC50 = 10.3 nM), making it a valuable tool for studying tumor proliferation and antitumor activity in various cancer research applications.
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