TETi76 is a potent inhibitor of TET family enzymes, demonstrating IC50 values of 1.5 μM for TET1, 9.4 μM for TET2, and 8.8 μM for TET3. By competitively binding to the active site of these enzymes, TETi76 effectively decreases cytosine hydroxymethylation and inhibits the clonal growth of TET2 mutant cells both in vitro and in vivo, while sparing normal hematopoietic precursor cells. This selective activity makes TETi76 a valuable tool for investigating leukemia and studying TET-related pathways in cancer research.
TETi76 is a potent inhibitor of TET family enzymes, demonstrating IC50 values of 1.5 μM for TET1, 9.4 μM for TET2, and 8.8 μM for TET3. By competitively binding to the active site of these enzymes, TETi76 effectively decreases cytosine hydroxymethylation and inhibits the clonal growth of TET2 mutant cells both in vitro and in vivo, while sparing normal hematopoietic precursor cells. This selective activity makes TETi76 a valuable tool for investigating leukemia and studying TET-related pathways in cancer research.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
