Thalidomide 4'-ether-PEG2-azide is a click chemistry-modified derivative of Thalidomide that functions as an E3 ubiquitin ligase ligand-linker conjugate. It features an azide group capable of participating in copper-catalyzed azide-alkyne cycloaddition reactions, making it suitable for conjugation with alkynyl-containing molecules. This reagent is particularly valuable in the development of Proteolysis Targeting Chimeras (PROTACs), enabling targeted protein degradation and advanced therapeutic strategies in cancer research and other areas of drug discovery.
Thalidomide 4'-ether-PEG2-azide is a click chemistry-modified derivative of Thalidomide that functions as an E3 ubiquitin ligase ligand-linker conjugate. It features an azide group capable of participating in copper-catalyzed azide-alkyne cycloaddition reactions, making it suitable for conjugation with alkynyl-containing molecules. This reagent is particularly valuable in the development of Proteolysis Targeting Chimeras (PROTACs), enabling targeted protein degradation and advanced therapeutic strategies in cancer research and other areas of drug discovery.
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