Thalidomide-4-OH-C11-OH is an E3 ligase ligand-linker conjugate designed to recruit the cereblon (CRBN) protein. This compound serves as a crucial intermediate in the synthesis of proteolysis-targeting chimeras (PROTACs), including various targeted degraders. Its application in the development of PROTACs facilitates targeted protein degradation, providing insights into cellular mechanisms and therapeutic opportunities in various diseases.
Thalidomide-4-OH-C11-OH is an E3 ligase ligand-linker conjugate designed to recruit the cereblon (CRBN) protein. This compound serves as a crucial intermediate in the synthesis of proteolysis-targeting chimeras (PROTACs), including various targeted degraders. Its application in the development of PROTACs facilitates targeted protein degradation, providing insights into cellular mechanisms and therapeutic opportunities in various diseases.
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