Thalidomide-5-F-6-azetidin-MeOH

Catalog No.: A80159
E3 Ligase Ligand-linker Conjugate
Thalidomide-5-F-6-azetidin-MeOH is an E3 ligase ligand-linker conjugate, specifically designed for the synthesis of PROTAC FLT3/CHK1 Degrader-1. This compound effectively targets and degrades FLT3 and CHK1, demonstrating significant anti-tumor activity. It serves as a valuable tool in drug development research, facilitating insights into targeted protein degradation mechanisms in cancer therapy.
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5mg
10mg
50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-5-F-6-azetidin-MeOH is an E3 ligase ligand-linker conjugate, specifically designed for the synthesis of PROTAC FLT3/CHK1 Degrader-1. This compound effectively targets and degrades FLT3 and CHK1, demonstrating significant anti-tumor activity. It serves as a valuable tool in drug development research, facilitating insights into targeted protein degradation mechanisms in cancer therapy.
Product Information
Catalog NumA80159
FormulaC17H16FN3O5
Molecular Weight361.32
CAS Number2934621-29-9
SMILESO=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=C(N4CC(CO)C4)C(F)=C3)=O
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