Thalidomide-5-O-CH2-COOH is an E3 ligase ligand-linker conjugate that functions as a selective ligand for the Cereblon (CRBN) protein. Its primary role is to facilitate the recruitment of CRBN, making it a valuable intermediate in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules targeting CRBN. This compound is essential for research related to targeted protein degradation and therapeutics aimed at modulating cellular proteins through ubiquitin-proteasome pathways.
Thalidomide-5-O-CH2-COOH is an E3 ligase ligand-linker conjugate that functions as a selective ligand for the Cereblon (CRBN) protein. Its primary role is to facilitate the recruitment of CRBN, making it a valuable intermediate in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules targeting CRBN. This compound is essential for research related to targeted protein degradation and therapeutics aimed at modulating cellular proteins through ubiquitin-proteasome pathways.
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