Thalidomide-5-(PEG2-amine) is an E3 ligase ligand-linker conjugate designed for use in the development of PROTACs (Proteolysis Targeting Chimeras). The compound features a terminal amine group that can undergo reaction with NHS esters or carboxylic acids in the presence of coupling agents such as EDC or HATU. The inclusion of a PEG spacer enhances the hydrophilicity and solubility in aqueous environments, making it suitable for biochemical applications and studies focused on targeted protein degradation.
Thalidomide-5-(PEG2-amine) is an E3 ligase ligand-linker conjugate designed for use in the development of PROTACs (Proteolysis Targeting Chimeras). The compound features a terminal amine group that can undergo reaction with NHS esters or carboxylic acids in the presence of coupling agents such as EDC or HATU. The inclusion of a PEG spacer enhances the hydrophilicity and solubility in aqueous environments, making it suitable for biochemical applications and studies focused on targeted protein degradation.
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