Thalidomide-5-PEG3-NH2 is an E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a polyethylene glycol (PEG) linker. This compound facilitates targeted protein degradation via the PROTAC (proteolysis-targeting chimera) technology, promoting ubiquitination and subsequent proteasomal degradation of specific proteins. Thalidomide-5-PEG3-NH2 is valuable for research applications investigating protein homeostasis and therapeutic strategies in various diseases, including cancer.
Thalidomide-5-PEG3-NH2 is an E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a polyethylene glycol (PEG) linker. This compound facilitates targeted protein degradation via the PROTAC (proteolysis-targeting chimera) technology, promoting ubiquitination and subsequent proteasomal degradation of specific proteins. Thalidomide-5-PEG3-NH2 is valuable for research applications investigating protein homeostasis and therapeutic strategies in various diseases, including cancer.
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