Thalidomide-azetidine-C-PIP-C-boc

Catalog No.: A31696
E3 Ligase Ligand-Linker Conjugate
Thalidomide-azetidine-C-PIP-C-boc is an E3 ligase ligand-linker conjugate that incorporates Thalidomide, serving as a recruiter for the cereblon (CRBN) protein. This compound facilitates the development of proteolysis-targeting chimeras (PROTACs) by acting as a critical intermediate for the synthesis of complete PROTAC molecules. Its utility in research includes applications in targeted protein degradation strategies, providing a platform for innovative therapeutic development.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-azetidine-C-PIP-C-boc is an E3 ligase ligand-linker conjugate that incorporates Thalidomide, serving as a recruiter for the cereblon (CRBN) protein. This compound facilitates the development of proteolysis-targeting chimeras (PROTACs) by acting as a critical intermediate for the synthesis of complete PROTAC molecules. Its utility in research includes applications in targeted protein degradation strategies, providing a platform for innovative therapeutic development.
Product Information
Catalog NumA31696
FormulaC27H35N5O6
Molecular Weight525.60
CAS Number2589699-87-4
SMILESO=C1NC(CCC1N2C(C3=C(C=CC(N4CC(C4)CN5CCN(CC5)CC(OC(C)(C)C)=O)=C3)C2=O)=O)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

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