Thalidomide fluoride

Catalog No.: A12144

Thalidomide-based Cereblon ligand

Thalidomide fluoride

Thalidomide fluoride Chemical Structure

CAS NO. 835616-60-9

Thalidomide fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).

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50 mg
$63.00
100 mg
$109.00
500 mg
$322.00
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Biological Activity

Thalidomide fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 36.2 mL 181.02 mL 362.03 mL
0.5 mM 7.24 mL 36.2 mL 72.41 mL
1 mM 3.62 mL 18.1 mL 36.2 mL
5 mM 0.72 mL 3.62 mL 7.24 mL

*The above data is based on the productmolecular weight 276.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12144
M. Wt 276.22
Formula C13H9FN2O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 835616-60-9
Synonyms Cereblon ligand 4; E3 ligase Ligand 4
SMILES O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3F)=O

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