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Thalidomide fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 36.2 mL | 181.02 mL | 362.03 mL |
| 0.5 mM | 7.24 mL | 36.2 mL | 72.41 mL |
| 1 mM | 3.62 mL | 18.1 mL | 36.2 mL |
| 5 mM | 0.72 mL | 3.62 mL | 7.24 mL |
*The above data is based on the productmolecular weight 276.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12144 |
|---|---|
| M. Wt | 276.22 |
| Formula | C13H9FN2O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 835616-60-9 |
| Synonyms | Cereblon ligand 4; E3 ligase Ligand 4 |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3F)=O |
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