Thalidomide-NH-C4-NH-Boc

Catalog No.: A31611
E3 Ligase Ligand-Linker Conjugates
Thalidomide-NH-C4-NH-Boc is an E3 ligase ligand-linker conjugate, featuring a cereblon ligand derived from Thalidomide and a specialized linker designed for PROTAC technology. This compound facilitates the targeted degradation of proteins by harnessing the ubiquitin-proteasome system, making it a valuable tool for researchers investigating protein turnover and cellular regulation. Its applications extend to drug discovery, developmental biology, and therapeutics, where selective protein modulation is critical.
Grouped product items
Size Price Stock Qty
5mg
$25.00
In stock
10mg
$40.00
In stock
25mg
$80.00
In stock
50mg
$130.00
In stock
100mg
$205.00
In stock
200mg
$280.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-NH-C4-NH-Boc is an E3 ligase ligand-linker conjugate, featuring a cereblon ligand derived from Thalidomide and a specialized linker designed for PROTAC technology. This compound facilitates the targeted degradation of proteins by harnessing the ubiquitin-proteasome system, making it a valuable tool for researchers investigating protein turnover and cellular regulation. Its applications extend to drug discovery, developmental biology, and therapeutics, where selective protein modulation is critical.
Product Information
Catalog NumA31611
FormulaC22H28N4O6
Molecular Weight444.48
CAS Number2093388-52-2
SMILESO=C(OC(C)(C)C)NCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

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    C2

    V2