Thalidomide-NH-C6-NH-Boc is an E3 ligase ligand-linker conjugate featuring a Thalidomide-derived cereblon ligand, designed for use in PROTAC (proteolysis-targeting chimera) applications. This compound serves as a crucial building block for synthesizing MI-389, a potent phthalimide-based degrader derived from the multi-targeted receptor tyrosine kinase inhibitor sunitinib. Thalidomide-NH-C6-NH-Boc enables targeted protein degradation, facilitating research into protein regulation and therapeutic discovery in oncology and other fields.
Thalidomide-NH-C6-NH-Boc is an E3 ligase ligand-linker conjugate featuring a Thalidomide-derived cereblon ligand, designed for use in PROTAC (proteolysis-targeting chimera) applications. This compound serves as a crucial building block for synthesizing MI-389, a potent phthalimide-based degrader derived from the multi-targeted receptor tyrosine kinase inhibitor sunitinib. Thalidomide-NH-C6-NH-Boc enables targeted protein degradation, facilitating research into protein regulation and therapeutic discovery in oncology and other fields.
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