Thalidomide-O-amide-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that features thalidomide as a cereblon ligand, combined with a five-carbon amine linker. This compound is designed for applications in Proteolysis Targeting Chimeras (PROTAC) technology, facilitating targeted protein degradation. Its mechanism involves the binding of the conjugate to E3 ligases, enabling the selective degradation of target proteins, which is useful in drug discovery and development for various therapeutic applications.
Thalidomide-O-amide-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that features thalidomide as a cereblon ligand, combined with a five-carbon amine linker. This compound is designed for applications in Proteolysis Targeting Chimeras (PROTAC) technology, facilitating targeted protein degradation. Its mechanism involves the binding of the conjugate to E3 ligases, enabling the selective degradation of target proteins, which is useful in drug discovery and development for various therapeutic applications.
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