Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA

Catalog No.: A31226
E3 Ligase Ligand-Linker Conjugates
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA is an engineered E3 ligase ligand-linker conjugate that features a Thalidomide-based cereblon ligand combined with a three-unit PEG linker suitable for PROTAC technology. This compound facilitates targeted protein degradation through selective E3 ligase recruitment, making it valuable for studies in cellular biology and therapeutic applications. Its unique structure enhances solubility and stability in biological systems, promoting efficient conjugation in research endeavors.
Grouped product items
Size Price Stock Qty
50mg
$535.00
In stock
100mg
$785.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA is an engineered E3 ligase ligand-linker conjugate that features a Thalidomide-based cereblon ligand combined with a three-unit PEG linker suitable for PROTAC technology. This compound facilitates targeted protein degradation through selective E3 ligase recruitment, making it valuable for studies in cellular biology and therapeutic applications. Its unique structure enhances solubility and stability in biological systems, promoting efficient conjugation in research endeavors.
Product Information
Catalog NumA31226
FormulaC27H35F3N4O11
Molecular Weight648.58
CAS Number2435572-49-7
SMILESOC(C(F)(F)F)=O.O=C(NCCOCCCOCCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
SynonymsCereblon Ligand-Linker Conjugates 12 TFA; E3 Ligase Ligand-Linker Conjugates 23 TFA
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