Thalidomide-O-amido-PEG2-C2-NH2 (TFA)

Catalog No.: A21634

E3 ligase ligand-linker conjugate

Thalidomide-O-amido-PEG2-C2-NH2 (TFA)

Thalidomide-O-amido-PEG2-C2-NH2 (TFA) Chemical Structure

CAS NO. 1957235-75-4

Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

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100 mg

Regular Price: $536.00

Special Price $428.80

500 mg

Regular Price: $1,609.00

Special Price $1,287.20

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Biological Activity

Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.35 mL 86.73 mL 173.47 mL
0.5 mM 3.47 mL 17.35 mL 34.69 mL
1 mM 1.73 mL 8.67 mL 17.35 mL
5 mM 0.35 mL 1.73 mL 3.47 mL

*The above data is based on the productmolecular weight 576.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21634
CAS No. 1957235-75-4
Formula C23H27F3N4O10
M. Wt 576.48
Purity >98%
Synonyms Cereblon Ligand-Linker Conjugates 10 (TFA); E3 Ligase Ligand-Linker Conjugates 24 (TFA)
SMILES O=C(NCCOCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.O=C(O)C(F)(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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