Thalidomide-O-amido-PEG2-C2-NH2

Catalog No.: A31565
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-amido-PEG2-C2-NH2 serves as an E3 ligase ligand-linker conjugate, playing a critical role in the modulation of immune responses. This compound exhibits immunomodulatory activity, making it relevant for cancer research and therapeutic applications. Its unique design allows for specific targeting of E3 ligases, facilitating the study of protein degradation pathways in cancer biology.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-O-amido-PEG2-C2-NH2 serves as an E3 ligase ligand-linker conjugate, playing a critical role in the modulation of immune responses. This compound exhibits immunomodulatory activity, making it relevant for cancer research and therapeutic applications. Its unique design allows for specific targeting of E3 ligases, facilitating the study of protein degradation pathways in cancer biology.
Product Information
Catalog NumA31565
FormulaC21H26N4O8
Molecular Weight462.45
CAS Number1957235-74-3
SMILESO=C(NCCOCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
SynonymsCereblon Ligand-Linker Conjugates 10; E3 Ligase Ligand-Linker Conjugates 24
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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