Thalidomide-O-C6-azide is an E3 ligase ligand-linker conjugate that combines the Thalidomide-based cereblon ligand with a versatile linker utilized in PROTAC technology. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Thalidomide-O-C6-azide is valuable for applications in targeted protein degradation and chemical biology studies.
Thalidomide-O-C6-azide is an E3 ligase ligand-linker conjugate that combines the Thalidomide-based cereblon ligand with a versatile linker utilized in PROTAC technology. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Thalidomide-O-C6-azide is valuable for applications in targeted protein degradation and chemical biology studies.
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