Thalidomide-O-PEG2-NHS ester

Catalog No.: A80421
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-PEG2-NHS ester is an E3 ligase ligand-linker conjugate that incorporates thalidomide-derived cereblon ligands with a PEG linker, facilitating targeted protein degradation via PROTAC technology. This compound is designed for use in research applications involving ubiquitin-proteasome system studies, enabling the modulation of protein levels in a cellular context. Its unique properties make it suitable for exploring therapeutics that can selectively eliminate disease-associated proteins.
Grouped product items
Size Price Stock Qty
50mg
$295.00
In stock
100mg
$450.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
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Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-O-PEG2-NHS ester is an E3 ligase ligand-linker conjugate that incorporates thalidomide-derived cereblon ligands with a PEG linker, facilitating targeted protein degradation via PROTAC technology. This compound is designed for use in research applications involving ubiquitin-proteasome system studies, enabling the modulation of protein levels in a cellular context. Its unique properties make it suitable for exploring therapeutics that can selectively eliminate disease-associated proteins.
Product Information
Catalog NumA80421
FormulaC24H25N3O11
Molecular Weight531.47
CAS Number2639395-34-7
SMILESO=C(CCOCCOCCOC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)ON4C(CCC4=O)=O
Useful Calculator

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