Thalidomide-O-PEG4-azide is an E3 ligase ligand-linker conjugate featuring a Thalidomide-based cereblon ligand. It serves as an essential component in PROTAC technology, facilitating targeted protein degradation. This compound is a versatile click chemistry reagent, containing an azide group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN moieties. These properties make it valuable for various bioconjugation applications in chemical biology and therapeutic research.
Thalidomide-O-PEG4-azide is an E3 ligase ligand-linker conjugate featuring a Thalidomide-based cereblon ligand. It serves as an essential component in PROTAC technology, facilitating targeted protein degradation. This compound is a versatile click chemistry reagent, containing an azide group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN moieties. These properties make it valuable for various bioconjugation applications in chemical biology and therapeutic research.
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